RACK7 a DNA damage response (DDR) protein, receptor for activated C-kinase (RACK) protein, and a transcriptional regulator. A bromodomain (BRD)-containing protein that recruits the nucleosome remodeling and histone deacetylation (NuRD) complex to damaged chromatin. Targets DNA damage within actively transcribed regions, repressing transcription, and promoting repair by homologous recombination. A cutaneous T-cell lymphoma-associated antigen that contains a bromodomain and two zinc fingers. Twenty-two alternatively spliced isoforms of the human protein hve been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component:  cytoplasm; dendritic shaft; dendritic spine; nucleus
Molecular Function:  lysine-acetylated histone binding; methylated histone binding; protein binding; protein domain specific binding; protein N-terminus binding; repressing transcription factor binding; transcription corepressor activity; zinc ion binding
Biological Process:  modulation of excitatory postsynaptic potential; negative regulation of cell migration; negative regulation of nucleic acid-templated transcription; positive regulation of dendritic spine development; positive regulation of dendritic spine maintenance; positive regulation of filopodium assembly; regulation of postsynaptic density protein 95 clustering; regulation of transcription, DNA-templated
Reference #:  Q9ULU4 (UniProtKB)
Alt. Names/Synonyms: CTCL tumor antigen se14-3; CTCL-associated antigen se14-3; cutaneous T-cell lymphoma associated antigen se14-3; Cutaneous T-cell lymphoma-associated antigen se14-3; KIAA1125; MGC31836; PKCB1; predicted protein of HQ2893; PRKCBP1; PRO2893; protein kinase C binding protein 1; Protein kinase C-binding protein 1; RACK7; zinc finger MYND domain containing protein 8; Zinc finger MYND domain-containing protein 8; zinc finger, MYND-type containing 8; ZMYND8
Gene Symbols: ZMYND8
Molecular weight: 131,692 Da
Basal Isoelectric point: 6.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RACK7

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein