ZHX1 Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. Belongs to the ZHX family. Ubiquitously expressed. Expressed in podocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 8q24.13
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding; protein heterodimerization activity; transcription corepressor activity
Biological Process:  cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated
Reference #:  Q9UKY1 (UniProtKB)
Alt. Names/Synonyms: ZHX1; zinc finger and homeodomain protein 1; zinc fingers and homeobox 1; zinc fingers and homeoboxes 1; Zinc fingers and homeoboxes protein 1; zinc-fingers and homeoboxes 1
Gene Symbols: ZHX1
Molecular weight: 98,098 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
Select Structure to View Below

ZHX1

Protein Structure Not Found.


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