CDC23 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC8/CDC23 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component:  anaphase-promoting complex; cytosol; nucleoplasm
Molecular Function:  protein binding; ubiquitin-protein transferase activity
Biological Process:  anaphase-promoting complex-dependent catabolic process; cell division; metaphase/anaphase transition of mitotic cell cycle; mitotic cell cycle; mitotic metaphase plate congression; protein K11-linked ubiquitination; regulation of exit from mitosis; regulation of mitotic cell cycle phase transition; regulation of mitotic metaphase/anaphase transition; ubiquitin-dependent protein catabolic process
Reference #:  Q9UJX2 (UniProtKB)
Alt. Names/Synonyms: ANAPC8; anaphase promoting complex subunit 8; Anaphase-promoting complex subunit 8; APC8; CDC23; cell division cycle 23 homolog (S. cerevisiae); Cell division cycle protein 23 homolog; Cyclosome subunit 8
Gene Symbols: CDC23
Molecular weight: 68,834 Da
Basal Isoelectric point: 6.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDC23

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene