FLT3 Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 13q12.2
Cellular Component:  cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; nucleus; plasma membrane
Molecular Function:  ATP binding; cytokine receptor activity; glucocorticoid receptor binding; protein binding; protein homodimerization activity; protein self-association; protein-containing complex binding; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor-activated receptor activity
Biological Process:  animal organ regeneration; B cell differentiation; cellular response to cytokine stimulus; cellular response to glucocorticoid stimulus; common myeloid progenitor cell proliferation; cytokine-mediated signaling pathway; dendritic cell differentiation; hemopoiesis; leukocyte homeostasis; lymphocyte proliferation; MAPK cascade; myeloid progenitor cell differentiation; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of tyrosine phosphorylation of STAT protein; pro-B cell differentiation; protein autophosphorylation; regulation of apoptotic process; response to organonitrogen compound; vascular endothelial growth factor signaling pathway; viral process
Disease: Leukemia, Acute Lymphoblastic; Leukemia, Acute Myeloid
Reference #:  P36888 (UniProtKB)
Alt. Names/Synonyms: CD135; CD135 antigen; fetal liver kinase 2; FL cytokine receptor; FLK2; FLT-3; FLT3; FLT3 receptor tyrosine kinase; Fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; Receptor-type tyrosine-protein kinase FLT3; Stem cell tyrosine kinase 1; STK-1; STK1; Tyrosine-protein kinase receptor FLT3
Gene Symbols: FLT3
Molecular weight: 112,903 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB