Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing. Belongs to the WAL family. Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nucleolus; Transcription regulation
Molecular Function: histone binding; lysine-acetylated histone binding; metal ion binding; nuclear receptor binding; protein binding; RNA binding; RNA polymerase I CORE element sequence-specific DNA binding
Biological Process: chromatin remodeling; chromatin silencing at rDNA; DNA methylation; histone deacetylation; regulation of transcription, DNA-templated; RNA polymerase I preinitiation complex assembly; transcription, DNA-templated