ZNF224 a probable transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. Belongs to the krueppel C2H2-type zinc-finger protein family. Ubiquitous. Mainly expressed in fetal tissues. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 19q13.31
Cellular Component:  nuclear membrane; nucleus; transcriptional repressor complex
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; protein binding; sequence-specific DNA binding
Biological Process:  negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated
Reference #:  Q9NZL3 (UniProtKB)
Alt. Names/Synonyms: BMZF-2; BMZF2; Bone marrow zinc finger 2; KOX22; zinc finger 2, bone marrow; Zinc finger protein 224; Zinc finger protein 233; Zinc finger protein 255; Zinc finger protein 27; zinc finger protein 27 (KOX 22); Zinc finger protein KOX22; zinc finger protein ZNF255; ZN224; ZNF224; ZNF233; ZNF255; ZNF27
Gene Symbols: ZNF224
Molecular weight: 82,280 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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