EVL Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. Required to transform actin polymerization into active movement for the propulsive force of Listeria monocytogenes. Belongs to the Ena/VASP family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14q32.2
Cellular Component:  cytoplasm; cytoskeleton; cytosol; focal adhesion; lamellipodium; phagocytic vesicle
Molecular Function:  actin binding; profilin binding; protein binding; SH3 domain binding
Biological Process:  actin filament organization; actin nucleation; actin polymerization or depolymerization; axon guidance; cell surface receptor signaling pathway; cellular response to interferon-gamma; negative regulation of epithelial cell migration; negative regulation of ruffle assembly; nervous system development; organ morphogenesis; positive regulation of stress fiber formation; protein homotetramerization
Reference #:  Q9UI08 (UniProtKB)
Alt. Names/Synonyms: Ena/vasodilator-stimulated phosphoprotein-like; Ena/VASP-like protein; Enah/Vasp-like; EVL; RNB6
Gene Symbols: EVL
Molecular weight: 44,620 Da
Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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EVL

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB