Trap240 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 13 family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 17q23.2
Cellular Component:  mediator complex; nucleoplasm; nucleus
Molecular Function:  nuclear receptor transcription coactivator activity; thyroid hormone receptor binding; transcription coactivator activity; transcription coregulator activity; vitamin D receptor binding
Biological Process:  cholesterol homeostasis; negative regulation of DNA-binding transcription factor activity; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; transcription initiation from RNA polymerase II promoter; triglyceride homeostasis
Disease: Intellectual Developmental Disorder 61
Reference #:  Q9UHV7 (UniProtKB)
Alt. Names/Synonyms: Activator-recruited cofactor 250 kDa component; ARC250; DRIP250; HSPC221; KIAA0593; MED13; Mediator complex subunit 13; Mediator of RNA polymerase II transcription subunit 13; mediator of RNA polymerase II transcription, subunit 13 homolog; MRD61; THRAP1; thyroid hormone receptor associated protein 1; Thyroid hormone receptor-associated protein 1; Thyroid hormone receptor-associated protein complex 240 kDa component; thyroid hormone receptor-associated protein complex component TRAP240; thyroid hormone receptor-associated protein, 240 kDa subunit; TRAP240; Vitamin D3 receptor-interacting protein complex component DRIP250
Gene Symbols: MED13
Molecular weight: 239,297 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene