HDAC6 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy. Belongs to the histone deacetylase family. HD type 2 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system

Chromosomal Location of human Ortholog: Xp11.23

Cellular Component: aggresome; axon; axon cytoplasm; caveola; cell leading edge; centrosome; ciliary basal body; cytoplasm; cytosol; dendrite; histone deacetylase complex; inclusion body; microtubule; microtubule associated complex; multivesicular body; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm

Molecular Function: acetylspermidine deacetylase activity; actin binding; alpha-tubulin binding; beta-catenin binding; beta-tubulin binding; dynein complex binding; enzyme binding; histone deacetylase activity; histone deacetylase binding; Hsp90 protein binding; microtubule binding; misfolded protein binding; polyubiquitin modification-dependent protein binding; protein binding; protein lysine deacetylase activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; tau protein binding; transcription corepressor binding; transcription factor binding; tubulin deacetylase activity; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding

Biological Process: aggresome assembly; autophagy; axonal transport of mitochondrion; cellular response to hydrogen peroxide; cellular response to misfolded protein; cellular response to parathyroid hormone stimulus; cellular response to topologically incorrect protein; cilium assembly; cilium disassembly; collateral sprouting; dendritic spine morphogenesis; epigenetic regulation of gene expression; histone deacetylation; Hsp90 deacetylation; intracellular protein transport; lysosome localization; negative regulation of axon extension involved in axon guidance; negative regulation of DNA-templated transcription; negative regulation of hydrogen peroxide metabolic process; negative regulation of microtubule depolymerization; negative regulation of oxidoreductase activity; negative regulation of protein acetylation; negative regulation of protein-containing complex assembly; negative regulation of protein-containing complex disassembly; negative regulation of proteolysis; negative regulation of transcription by RNA polymerase II; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; peptidyl-lysine deacetylation; polyamine deacetylation; polyubiquitinated misfolded protein transport; positive regulation of cellular response to oxidative stress; positive regulation of cholangiocyte proliferation; positive regulation of dendrite morphogenesis; positive regulation of epithelial cell migration; positive regulation of peptidyl-serine phosphorylation; positive regulation of signaling receptor activity; positive regulation of synaptic transmission, glutamatergic; positive regulation of tubulin deacetylation; protein deacetylation; protein destabilization; protein polyubiquitination; protein quality control for misfolded or incompletely synthesized proteins; protein-containing complex disassembly; regulation of androgen receptor signaling pathway; regulation of autophagy; regulation of autophagy of mitochondrion; regulation of establishment of protein localization; regulation of fat cell differentiation; regulation of macroautophagy; regulation of microtubule-based movement; regulation of protein stability; response to amphetamine; response to corticosterone; response to dexamethasone; response to growth factor; response to immobilization stress; response to misfolded protein; spermidine deacetylation; tubulin deacetylation; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Disease: Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia

Reference #: Q9UBN7 (UniProtKB)

Alt. Names/Synonyms: CPBHM; FLJ16239; HD6; HDAC6; Histone deacetylase 6; JM21; KIAA0901; PPP1R90; protein phosphatase 1, regulatory subunit 90; Tubulin-lysine deacetylase HDAC6

Gene Symbols: HDAC6

Molecular weight: 131,419 Da

Basal Isoelectric point: 5.14 Predict pI for various phosphorylation states

CST Pathways: G1/S Checkpoint | NF-kB Signaling | Protein Acetylation | Wnt/ß-Catenin Signaling

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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HDAC6

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