CPSF2 Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily. Note: This description may include information from UniProtKB.
Protein type: RNA splicing
Chromosomal Location of human Ortholog: 14q32.12
Cellular Component:  mRNA cleavage and polyadenylation specificity factor complex; nucleoplasm
Molecular Function:  protein binding; RNA binding
Biological Process:  mRNA 3'-end processing; mRNA 3'-end processing by stem-loop binding and cleavage; mRNA cleavage; mRNA export from nucleus; mRNA polyadenylation; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription
Reference #:  Q9P2I0 (UniProtKB)
Alt. Names/Synonyms: cleavage and polyadenylation specific factor 2; cleavage and polyadenylation specific factor 2, 100kDa; Cleavage and polyadenylation specificity factor 100 kDa subunit; Cleavage and polyadenylation specificity factor subunit 2; CPSF 100 kDa subunit; CPSF 100kDa subunit; CPSF100; CPSF2; KIAA1367
Gene Symbols: CPSF2
Molecular weight: 88,487 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
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CPSF2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB