midasin Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus. At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm. Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex. This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation. Belongs to the midasin family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Nucleolus
Chromosomal Location of human Ortholog: 6q15
Cellular Component:  cytosol; intermediate filament cytoskeleton; nucleolus; nucleoplasm; nucleus
Molecular Function:  ATP binding; ATPase activity; protein binding; unfolded protein binding
Biological Process:  protein-containing complex assembly
Reference #:  Q9NU22 (UniProtKB)
Alt. Names/Synonyms: DKFZp686H16106; Dynein-related AAA-ATPase MDN1; FLJ23395; FLJ25587; FLJ42031; FLJ43191; KIAA0301; MDN1; MDN1, midasin homolog; MDN1, midasin homolog (yeast); MIDAS-containing protein; Midasin; midasin AAA ATPase 1; Rea1
Gene Symbols: MDN1
Molecular weight: 632,820 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene