SMC4 Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Belongs to the SMC family. SMC4 subfamily. Widely expressed. Higher expression in testis, colon, thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of human Ortholog: 3q25.33
Cellular Component:  condensin complex; cytosol; nuclear speck; nucleoplasm; nucleus
Molecular Function:  ATP binding; protein binding; protein heterodimerization activity; single-stranded DNA binding
Biological Process:  cell division; kinetochore organization; meiotic chromosome condensation; meiotic chromosome segregation; mitotic chromosome condensation; mitotic sister chromatid segregation
Reference #:  Q9NTJ3 (UniProtKB)
Alt. Names/Synonyms: CAP-C; CAPC; Chromosome-associated polypeptide C; hCAP-C; SMC protein 4; SMC-4; SMC4; SMC4 structural maintenance of chromosomes 4-like 1; SMC4L1; structural maintenance of chromosomes 4; Structural maintenance of chromosomes protein 4; XCAP-C homolog
Gene Symbols: SMC4
Molecular weight: 147,182 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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