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SMC4
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Belongs to the SMC family. SMC4 subfamily. Widely expressed. Higher expression in testis, colon, thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation |
| Chromosomal Location of human Ortholog: 3q25.33 |
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Cellular Component:
chromosome, centromeric region; condensed nuclear chromosome; condensin complex; cytosol; nuclear speck; nucleoplasm; nucleus
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Molecular Function:
ATP binding; ATP hydrolysis activity; chromatin binding; protein binding; single-stranded DNA binding
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Biological Process:
cell division; kinetochore organization; meiotic chromosome condensation; meiotic chromosome segregation; mitotic chromosome condensation; mitotic sister chromatid segregation; positive regulation of chromosome condensation; positive regulation of chromosome segregation; positive regulation of chromosome separation
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Reference #:
Q9NTJ3
(UniProtKB)
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Alt. Names/Synonyms: CAP-C; CAPC; Chromosome-associated polypeptide C; hCAP-C; SMC protein 4; SMC-4; SMC4; SMC4 structural maintenance of chromosomes 4-like 1; SMC4L1; structural maintenance of chromosomes 4; Structural maintenance of chromosomes protein 4; XCAP-C homolog
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Gene Symbols: SMC4
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Molecular weight:
147,182 Da
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Basal Isoelectric point:
6.37
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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