RPRD1B Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. Belongs to the UPF0400 (RTT103) family. Preferentially expressed in a range of tumor tissues including colon, lung, liver, breast, prostate, stomach, uterine endometrium and cervical cancers with higher levels in tumors than in adjacent non-tumor tissue (at protein level). Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 20q11.23
Cellular Component:  centrosome; cytosol; nucleoplasm; nucleus; RNA polymerase II, holoenzyme
Molecular Function:  identical protein binding; protein binding; RNA polymerase II complex binding
Biological Process:  dephosphorylation of RNA polymerase II C-terminal domain; positive regulation of cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of cell cycle process; snRNA transcription by RNA polymerase II
Reference #:  Q9NQG5 (UniProtKB)
Alt. Names/Synonyms: C20orf77; Cell cycle-related and expression-elevated protein in tumor; cell-cycle related and expression-elevated protein in tumor; CREPT; dJ1057B20.2; DKFZp434P0735; FLJ44520; K-H; Ku70-binding protein 5-Hera; Kub5-Hera; NET60; regulation of nuclear pre-mRNA domain containing 1B; Regulation of nuclear pre-mRNA domain-containing protein 1B; RPR1B; RPRD1B
Gene Symbols: RPRD1B
Molecular weight: 36,900 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
Select Structure to View Below

RPRD1B

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene