FAK a tyrosine kinase of the FAK family required for cell migration and contact-dependent survival signaling. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Downstream of integrins and Src, upstream of Ras/MAPK. Localizes to focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with Shb. Required for full Ras transformation of fibroblasts. Increased expression in breast and other cancers, related to chromosome 8q amplification. Overexpression and activation associated with increased migration, invasion and progression of ovarian cancer, and with progression in hepatocellular carcinoma, thyroid cancer, and acute myelogenous leukemia. siRNA increases chemosensitivity of pancreatic adenocarcinoma xenografts. Inhibitor: ISI15421 (antisense). Four splice-variant isoforms have been observed. Note: This description may include information from UniProtKB.
Protein type: EC; Fak family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component:  adherens junction; apical plasma membrane; cell cortex; cytoplasm; cytoskeleton; cytosol; focal adhesion; lamellipodium; microtubule organizing center; nucleus; plasma membrane; stress fiber
Molecular Function:  actin binding; ATP binding; JUN kinase binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein tyrosine kinase activity; SH2 domain binding
Biological Process:  angiogenesis; axon guidance; cell motility; central nervous system neuron axonogenesis; endothelial cell migration; ephrin receptor signaling pathway; establishment of cell polarity; extracellular matrix organization; Fc-gamma receptor signaling pathway involved in phagocytosis; growth hormone receptor signaling pathway; heart morphogenesis; integrin-mediated signaling pathway; MAPK cascade; microtubule cytoskeleton organization; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of axonogenesis; negative regulation of cell-cell adhesion; negative regulation of organ growth; negative regulation of synapse assembly; netrin-activated signaling pathway; neuron migration; nuclear migration; peptidyl-tyrosine phosphorylation; placenta development; positive regulation of cardiac muscle hypertrophy; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of ubiquitin-dependent protein catabolic process; protein autophosphorylation; regulation of cell adhesion mediated by integrin; regulation of cell proliferation; regulation of cell shape; regulation of cytoskeleton organization; regulation of endothelial cell migration; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of GTPase activity; regulation of osteoblast differentiation; regulation of protein phosphorylation; regulation of substrate adhesion-dependent cell spreading; signal complex assembly; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; vasculogenesis
Reference #:  Q05397 (UniProtKB)
Alt. Names/Synonyms: FADK; FADK 1; FAK; FAK-related non-kinase polypeptide; FAK1; Focal adhesion kinase 1; FRNK; pp125FAK; Protein-tyrosine kinase 2; PTK2; PTK2 protein tyrosine kinase 2
Gene Symbols: PTK2
Molecular weight: 119,233 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene