ABCB9 ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component:  integral component of endoplasmic reticulum membrane; integral component of membrane; intracellular membrane-bounded organelle; lysosomal membrane; lysosome
Molecular Function:  ATP binding; peptide-transporting ATPase activity; protein binding; protein homodimerization activity; transmembrane transporter activity
Biological Process:  peptide transport; protein transport; transmembrane transport
Reference #:  Q9NP78 (UniProtKB)
Alt. Names/Synonyms: ABC transporter 9 protein; ABCB9; ATP binding cassette subfamily B member 9; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ATP-binding cassette, sub-family B (MDR/TAP), member 9; EST122234; hABCB9; KIAA1520; TAP-like protein; TAPL
Gene Symbols: ABCB9
Molecular weight: 84,475 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below

ABCB9

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene