ECT2 Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. Expressed in lung epithelial cells (at protein level). Expressed in squamous cell carcinoma, primary non-small cell lung cancer tumors and lung adenocarcinoma. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q26.31
Cellular Component:  bicellular tight junction; cell-cell junction; centralspindlin complex; cleavage furrow; cytoplasm; cytosol; midbody; mitotic spindle; nucleus
Molecular Function:  GTPase activator activity; protein binding; protein homodimerization activity; Rho guanyl-nucleotide exchange factor activity
Biological Process:  activation of GTPase activity; activation of protein kinase activity; bicellular tight junction assembly; cell morphogenesis; cellular response to calcium ion; cellular response to hydrogen peroxide; cellular response to ionizing radiation; G protein-coupled receptor signaling pathway; intracellular signal transduction; mitotic cytokinesis; positive regulation of apoptotic process; positive regulation of cytokinesis; positive regulation of GTPase activity; positive regulation of neuron differentiation; positive regulation of protein import into nucleus; protein homooligomerization; protein transport; regulation of attachment of spindle microtubules to kinetochore; regulation of cytokinesis, actomyosin contractile ring assembly; regulation of protein kinase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction
Reference #:  Q9H8V3 (UniProtKB)
Alt. Names/Synonyms: ARHGEF31; ECT2; epithelial cell transforming sequence 2 oncogene; Epithelial cell-transforming sequence 2 oncogene; FLJ10461; MGC138291; Protein ECT2
Gene Symbols: ECT2
Molecular weight: 103,505 Da
Basal Isoelectric point: 7.77  Predict pI for various phosphorylation states
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ECT2

Protein Structure Not Found.


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