PCIF1 Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs. Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally. N6-methylation of m6A(m) promotes the translation of capped mRNAs. Belongs to the CAPAM family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: RNA processing
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component:  intercellular bridge; microtubule cytoskeleton; nucleoplasm; nucleus
Molecular Function:  mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; RNA polymerase II C-terminal domain binding; S-adenosyl-L-methionine binding
Biological Process:  mRNA methylation; negative regulation of phosphatase activity; positive regulation of translation
Reference #:  Q9H4Z3 (UniProtKB)
Alt. Names/Synonyms: C20orf67; Cap-specific adenosine methyltransferase; CAPAM; hCAPAM; hPCIF1; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; PCIF1; PDX-1 C terminus-interacting factor 1; PDX1 C-terminal inhibiting factor 1; phosphorylated CTD interacting factor 1; Phosphorylated CTD-interacting factor 1; PPP1R121; Protein phosphatase 1 regulatory subunit 121; protein phosphatase 1, regulatory subunit 121
Gene Symbols: PCIF1
Molecular weight: 80,670 Da
Basal Isoelectric point: 7.09  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene