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PCIF1
Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs. Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally. N6-methylation of m6A(m) promotes the translation of capped mRNAs. Belongs to the CAPAM family. Ubiquitous. Note: This description may include information from UniProtKB.
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| Protein type: RNA processing |
| Chromosomal Location of human Ortholog: 20q13.12 |
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Cellular Component:
intercellular bridge; microtubule cytoskeleton; nucleoplasm; nucleus
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Molecular Function:
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; RNA polymerase II C-terminal domain binding; RNA polymerase II C-terminal domain phosphoserine binding; S-adenosyl-L-methionine binding
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Biological Process:
mRNA methylation; negative regulation of translation; positive regulation of translation; regulation of translation
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Reference #:
Q9H4Z3
(UniProtKB)
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Alt. Names/Synonyms: C20orf67; Cap-specific adenosine methyltransferase; CAPAM; hCAPAM; hPCIF1; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; PCIF1; PDX-1 C terminus-interacting factor 1; PDX1 C-terminal inhibiting factor 1; phosphorylated CTD interacting factor 1; Phosphorylated CTD-interacting factor 1; PPP1R121; Protein phosphatase 1 regulatory subunit 121; protein phosphatase 1, regulatory subunit 121
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Gene Symbols: PCIF1
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Molecular weight:
80,670 Da
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Basal Isoelectric point:
7.09
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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