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SMARCAD1
DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. Belongs to the SNF2/RAD54 helicase family. Isoform 1 is expressed ubiquitously. Isoform 3 is expressed mainly in skin, fibroblasts, keratinocytes and esophagus. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; EC 3.6.4.12; Helicase |
| Chromosomal Location of human Ortholog: 4q22.3 |
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Cellular Component:
heterochromatin; nuclear replication fork; nucleoplasm; nucleus; site of double-strand break
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Molecular Function:
ATP binding; ATP hydrolysis activity; ATP-dependent activity, acting on DNA; ATP-dependent chromatin remodeler activity; chromatin binding; DNA binding; helicase activity; protein binding; ubiquitin binding
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Biological Process:
chromatin remodeling; chromosome separation; DNA double-strand break processing; regulation of DNA recombination
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Disease: Adermatoglyphia; Basan Syndrome; Huriez Syndrome
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Reference #:
Q9H4L7
(UniProtKB)
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Alt. Names/Synonyms: ADERM; ATP-dependent helicase 1; BASNS; DKFZp762K2015; ETL1; HEL1; hHEL1; HRZ; KIAA1122; SMARCAD1; SMRCD; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1; SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
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Gene Symbols: SMARCAD1
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Molecular weight:
117,402 Da
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Basal Isoelectric point:
5.39
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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