ZHX3 Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. Belongs to the ZHX family. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 20q12
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process:  cell differentiation; negative regulation of transcription, DNA-templated; positive regulation of osteoblast differentiation
Reference #:  Q9H4I2 (UniProtKB)
Alt. Names/Synonyms: KIAA0395; TIX1; triple homeobox 1; Triple homeobox protein 1; ZHX3; Zinc finger and homeodomain protein 3; zinc fingers and homeoboxes 3; Zinc fingers and homeoboxes protein 3
Gene Symbols: ZHX3
Molecular weight: 104,658 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
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ZHX3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene