WHSC2 Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Belongs to the NELF-A family. Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 4p16.3
Cellular Component:  cytosol; NELF complex; nuclear body; nucleoplasm; nucleus
Molecular Function:  chromatin binding; molecular adaptor activity; protein binding
Biological Process:  negative regulation of transcription elongation by RNA polymerase II; positive regulation of histone H3-K4 methylation; positive regulation of transcription by RNA polymerase II
Reference #:  Q9H3P2 (UniProtKB)
Alt. Names/Synonyms: Negative elongation factor A; negative elongation factor complex member A; NELF-A; NELFA; P/OKcl.15; WHSC2; Wolf-Hirschhorn syndrome candidate 2; Wolf-Hirschhorn syndrome candidate 2 protein
Gene Symbols: NELFA
Molecular weight: 57,277 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein