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NUCKS
Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver, thymus and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of Human Ortholog: 1q32.1 |
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Cellular Component:
chromatin; cytoplasm; nuclear chromatin; nucleolus; nucleus
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Molecular Function:
chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; double-stranded DNA binding; single-stranded DNA binding; transcription factor binding
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Biological Process:
cellular glucose homeostasis; cellular response to X-ray; chromatin organization; double-strand break repair via homologous recombination; gene conversion; interstrand cross-link repair; modulation by host of RNA binding by virus; modulation by host of viral RNA-binding transcription factor activity; positive regulation by host of viral genome replication; positive regulation by host of viral transcription; positive regulation of insulin receptor signaling pathway; positive regulation of transcription by RNA polymerase II; regulation of DNA replication; regulation of DNA strand elongation; regulation of insulin receptor signaling pathway; regulation of transcription by RNA polymerase II; release from viral latency; replication fork processing
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Reference #:
Q9H1E3
(UniProtKB)
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Alt. Names/Synonyms: FLJ21480; FLJ32016; FLJ38536; JC7; NUCKS; NUCKS1; nuclear casein kinase and cyclin dependent kinase substrate 1; nuclear casein kinase and cyclin-dependent kinase substrate 1; Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1; Nuclear ubiquitous casein and cyclin-dependent kinases substrate; nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate; P1; potential LAG1 interactor
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Gene Symbols: NUCKS1
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Molecular weight:
27,296 Da
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Basal Isoelectric point:
5
Predict pI for various phosphorylation states
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