PRDM14 a probable protein lysine methyltransferase that works in concert with the core human embryonic stem cell (ESC) regulators to control pluripotency associated genes. Binds to silenced genes in human ESCs. Its binding profile is enriched for the repressive tri-methylation of histone H3 lysine 27 (H3K27me3) modification. Interacts directly with the polycomb repressive complex 2 (PRC2). PRC2 is detected at PRDM14-bound loci in human ESCs. A probable transcriptional regulator of the krueppel C2H2-type zinc-finger protein family. Has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming. Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Methyltransferase, protein arginine, predicted
Chromosomal Location of Human Ortholog: 8q13.3
Cellular Component:  nucleoplasm
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; methyltransferase activity; protein binding; RNA binding
Biological Process:  cell fate specification; cell morphogenesis; embryo implantation; fertilization; germ cell development; germ-line stem cell population maintenance; homeostasis of number of cells within a tissue; inactivation of paternal X chromosome; inner cell mass cell fate commitment; negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of flagellated sperm motility; positive regulation of stem cell population maintenance; regulation of DNA methylation; somatic stem cell population maintenance
Reference #:  Q9GZV8 (UniProtKB)
Alt. Names/Synonyms: MGC59730; PFM11; PR domain containing 14; PR domain zinc finger protein 14; PR domain-containing protein 14; PR-domain zinc finger protein 14; PRD14; PRDM14
Gene Symbols: PRDM14
Molecular weight: 64,062 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PRDM14

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene