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PRDM14
Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation. Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. Belongs to the class V-like SAM-binding methyltransferase superfamily. Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; Methyltransferase, protein arginine, predicted |
| Chromosomal Location of human Ortholog: 8q13.3 |
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Cellular Component:
nucleoplasm; nucleus
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Molecular Function:
chromatin DNA binding; metal ion binding; methyltransferase activity; protein binding; RNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding
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Biological Process:
cell fate specification; cell morphogenesis; embryo implantation; fertilization; fibroblast growth factor receptor signaling pathway; germ cell development; germ-line stem cell population maintenance; histone H3-R26 methylation; homeostasis of number of cells within a tissue; inactivation of paternal X chromosome; inner cell mass cell fate commitment; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of transcription by RNA polymerase II; positive regulation of flagellated sperm motility; positive regulation of stem cell population maintenance; regulation of DNA methylation; regulation of transcription by RNA polymerase II
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Reference #:
Q9GZV8
(UniProtKB)
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Alt. Names/Synonyms: MGC59730; PFM11; PR domain 14; PR domain containing 14; PR domain zinc finger protein 14; PR domain-containing 14; PR domain-containing protein 14; PR-domain zinc finger protein 14; PR/SET domain 14; PRD14; PRDM14
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Gene Symbols: PRDM14
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Molecular weight:
64,062 Da
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Basal Isoelectric point:
6.65
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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