PRIC285 Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. Belongs to the DNA2/NAM7 helicase family. Expressed in various tissues including heart, pancreas, skeletal muscle, colon, spleen, liver, kidney, lung, peripheral blood and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 20q13.33
Cellular Component:  cytoplasm; nucleoplasm
Molecular Function:  ATP binding; DNA binding; metal ion binding; nuclear receptor coactivator activity; protein binding; ribonuclease activity; RNA binding; RNA helicase activity
Biological Process:  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of transcription by RNA polymerase II; RNA phosphodiester bond hydrolysis
Reference #:  Q9BYK8 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase PRIC285; FLJ00244; helicase with zinc finger 2; Helicase with zinc finger 2, transcriptional coactivator; Helicase with zinc finger domain 2; HELZ2; KIAA1769; MGC132634; MGC138228; PDIP-1; PDIP1; peroxisomal proliferator-activated receptor A interacting complex 285; Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein; peroxisomal proliferator-activated receptor alpha-interacting cofactor complex, 285 kD subunit; PPAR gamma DBD-interacting protein 1; PPAR-alpha-interacting complex protein 285; PPAR-gamma DBD-interacting protein 1; PPAR-gamma DNA-binding domain-interacting protein 1; PPARG-DBD-interacting protein 1; PPARgamma-DNA-binding domain-interacting protein1; PR285; PRIC complex; PRIC285
Gene Symbols: HELZ2
Molecular weight: 294,651 Da
Basal Isoelectric point: 7.36  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein