DATF1 Putative transcription factor, weakly pro-apoptotic when overexpressed. Tumor suppressor. Required for early embryonic stem cell development. Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of human Ortholog: 20q13.33
Cellular Component:  cytoplasm; nucleus; spindle
Molecular Function:  metal ion binding
Biological Process:  apoptotic signaling pathway; DNA-templated transcription
Reference #:  Q9BTC0 (UniProtKB)
Alt. Names/Synonyms: BYE1; C20orf158; DATF-1; DATF1; death associated transcription factor 1; death inducer-obliterator 1; Death-associated transcription factor 1; Death-inducer obliterator 1; DIDO1; DIDO2; DIDO3; DIO-1; DIO1; dJ885L7.8; DKFZp434P1115; FLJ11265; hDido1; KIAA0333; MGC16140
Gene Symbols: DIDO1
Molecular weight: 243,873 Da
Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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DATF1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein