ERK3 a protein kinase of the MAPK family. Plays a critical role in the regulation of cell growth and differentiation. Localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC; ERK subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 15q21.2
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; protein-containing complex; septin cytoskeleton
Molecular Function:  ATP binding; MAP kinase activity; protein binding; protein heterodimerization activity; protein kinase binding; protein serine/threonine kinase activity
Biological Process:  cell cycle; MAPK cascade; positive regulation of dendritic spine development; protein phosphorylation; signal transduction
Reference #:  Q16659 (UniProtKB)
Alt. Names/Synonyms: DKFZp686F03189; ERK-3; ERK3; Extracellular signal-regulated kinase 3; extracellular signal-regulated kinase, p97; HsT17250; MAP kinase 6; MAP kinase isoform p97; MAPK 6; MAPK6; Mitogen-activated protein kinase 6; MK06; p97-MAPK; p97MAPK; PRKM6; protein kinase, mitogen-activated 5; protein kinase, mitogen-activated 6
Gene Symbols: MAPK6
Molecular weight: 82,681 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB