|
ERK3
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts. Note: This description may include information from UniProtKB.
|
| Protein type: CMGC group; EC 2.7.11.24; ERK3 subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 15q21.2 |
|
Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus; protein-containing complex; septin cytoskeleton
|
|
Molecular Function:
ATP binding; MAP kinase activity; protein binding; protein heterodimerization activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity
|
|
Biological Process:
cell cycle; intracellular signal transduction; MAPK cascade; positive regulation of dendritic spine development; protein phosphorylation; signal transduction
|
|
Reference #:
Q16659
(UniProtKB)
|
|
Alt. Names/Synonyms: DKFZp686F03189; ERK-3; ERK3; Extracellular signal-regulated kinase 3; extracellular signal-regulated kinase, p97; HsT17250; MAP kinase 6; MAP kinase isoform p97; MAPK 6; MAPK6; Mitogen-activated protein kinase 6; MK06; p97-MAPK; p97MAPK; PRKM6; protein kinase, mitogen-activated 5; protein kinase, mitogen-activated 6
|
|
Gene Symbols: MAPK6
|
|
Molecular weight:
82,681 Da
|
|
Basal Isoelectric point:
4.91
Predict pI for various phosphorylation states
|
|
CST Pathways:
ErbB/HER Signaling
|
GPCR Signaling to MAPKs
|
IL6 Signaling
|
Microtubule Dynamics
|
mTOR Signaling
|
Translation: eIF4E and p70S6K
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
