SHARP May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. Belongs to the RRM Spen family. Expressed at high level in brain, testis, spleen and thymus. Expressed at intermediate level in kidney, liver, mammary gland and skin. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; RNA-binding; Spliceosome; Transcription factor
Chromosomal Location of Human Ortholog: 1p36.21-p36.13
Cellular Component:  nucleoplasm; transcriptional repressor complex
Molecular Function:  DNA binding; protein binding; RNA polymerase II transcription factor binding; transcription corepressor activity
Biological Process:  negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; Notch signaling pathway; positive regulation of neurogenesis; viral process
Reference #:  Q96T58 (UniProtKB)
Alt. Names/Synonyms: HIAA0929; KIAA0929; MINT; Msx2 interacting nuclear target (MINT) homolog; Msx2-interacting protein; nuclear receptor transcription cofactor; RBM15C; RP1-134O19.1; SHARP; SMART/HDAC1 associated repressor protein; SMART/HDAC1-associated repressor protein; SPEN; spen family transcriptional repressor; SPEN homolog; spen homolog, transcriptional regulator; spen homolog, transcriptional regulator (Drosophila)
Gene Symbols: SPEN
Molecular weight: 402,248 Da
Basal Isoelectric point: 7.35  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA