CENTG3 GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. Belongs to the centaurin gamma-like family. Widely expressed. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF
Chromosomal Location of human Ortholog: 7q36.1
Cellular Component:  cell periphery; cytoplasm; membrane; nucleus
Molecular Function:  GTP binding; GTPase activator activity; GTPase activity; metal ion binding; polyubiquitin modification-dependent protein binding
Biological Process:  cellular response to reactive oxygen species; positive regulation of GTPase activity; proteasome-mediated ubiquitin-dependent protein catabolic process; signal transduction
Reference #:  Q96P47 (UniProtKB)
Alt. Names/Synonyms: AGAP-3; AGAP3; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; centaurin, gamma 3; Centaurin-gamma-3; CENTG3; Cnt-g3; CRAG; CRAM-associated GTPase; CRMP (collapsin response mediator protein) associated; FLJ16146; FLJ34452; MR1-interacting protein; MRIP-1
Gene Symbols: AGAP3
Molecular weight: 95,044 Da
Basal Isoelectric point: 8.22  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein