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CENTG3
GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. Belongs to the centaurin gamma-like family. Widely expressed. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, ARF |
| Chromosomal Location of human Ortholog: 7q36.1 |
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Cellular Component:
cell periphery; cytoplasm; nucleus
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Molecular Function:
GTP binding; GTPase activator activity; GTPase activity; metal ion binding; polyubiquitin modification-dependent protein binding
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Biological Process:
activation of GTPase activity; cellular response to reactive oxygen species; proteasome-mediated ubiquitin-dependent protein catabolic process
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Reference #:
Q96P47
(UniProtKB)
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Alt. Names/Synonyms: AGAP-3; AGAP3; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; centaurin, gamma 3; Centaurin-gamma-3; CENTG3; Cnt-g3; CRAG; CRAM-associated GTPase; CRMP (collapsin response mediator protein) associated; FLJ16146; FLJ34452; MR1-interacting protein; MRIP-1
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Gene Symbols: AGAP3
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Molecular weight:
95,044 Da
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Basal Isoelectric point:
8.22
Predict pI for various phosphorylation states
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