DOCK7
Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3. Belongs to the DOCK family. Widely expressed. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: GEF; GEF, misc. |
Chromosomal Location of human Ortholog: 1p31.3 |
Cellular Component:
axon; basal part of cell; growth cone; neuron projection
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Molecular Function:
guanyl-nucleotide exchange factor activity; protein binding; small GTPase binding
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Biological Process:
activation of GTPase activity; axonogenesis; establishment of neuroblast polarity; interkinetic nuclear migration; microtubule cytoskeleton organization; negative regulation of cold-induced thermogenesis; neuron projection development; positive regulation of GTPase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of vascular associated smooth muscle cell migration; regulation of neurogenesis; small GTPase mediated signal transduction
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Disease: Epileptic Encephalopathy, Early Infantile, 23
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Reference #:
Q96N67
(UniProtKB)
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Alt. Names/Synonyms: dedicator of cytokinesis 7; Dedicator of cytokinesis protein 7; DOCK7; EIEE23; KIAA1771; ZIR2
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Gene Symbols: DOCK7
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Molecular weight:
242,561 Da
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Basal Isoelectric point:
6.34
Predict pI for various phosphorylation states
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