YT521 Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10. Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing. May also regulate alternative splice site selection. Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. Also recognizes and binds m6A on other RNA molecules. Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist. Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of human Ortholog: 4q13.2
Cellular Component:  nuclear speck; nucleoplasm; nucleus; plasma membrane
Molecular Function:  mRNA binding; N6-methyladenosine-containing RNA binding; protein binding; RNA binding
Biological Process:  dosage compensation by inactivation of X chromosome; in utero embryonic development; mRNA alternative polyadenylation; mRNA export from nucleus; mRNA splice site selection; mRNA splicing, via spliceosome; post-transcriptional regulation of gene expression; primary follicle stage; regulation of alternative mRNA splicing, via spliceosome; regulation of mRNA splicing, via spliceosome; spermatogenesis
Reference #:  Q96MU7 (UniProtKB)
Alt. Names/Synonyms: KIAA1966; Putative splicing factor YT521; Splicing factor YT521; splicing factor YT521-B; YT521; YT521-B; YTDC1; YTH domain containing 1; YTH domain-containing protein 1; YTHDC1
Gene Symbols: YTHDC1
Molecular weight: 84,700 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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YT521

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein