VCIP135
Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. Note: This description may include information from UniProtKB.
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Protein type: Cell cycle regulation; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease |
Chromosomal Location of human Ortholog: 8q13.1 |
Cellular Component:
cytoplasm; endoplasmic reticulum lumen; Golgi stack; nucleus
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Molecular Function:
cysteine-type deubiquitinase activity
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Biological Process:
DNA damage response; endoplasmic reticulum membrane fusion; Golgi reassembly; protein deubiquitination; protein K11-linked deubiquitination; protein K48-linked deubiquitination; protein ubiquitination; protein-DNA covalent cross-linking repair; regulation of protein localization to chromatin
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Reference #:
Q96JH7
(UniProtKB)
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Alt. Names/Synonyms: Deubiquitinating protein VCIP135; Deubiquitinating protein VCPIP1; DKFZp686G038; DUBA3; FLJ23132; FLJ60694; KIAA1850; valosin containing protein (p97)/p47 complex interacting protein 1; valosin containing protein interacting protein 1; valosin-containing protein (p97)/p47 complex-interacting protein p135; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; VCIP1; VCIP135; VCP/p47 complex-interacting 135-kDa protein; VCPIP1
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Gene Symbols: VCPIP1
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Molecular weight:
134,321 Da
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Basal Isoelectric point:
6.77
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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