VCIP135 Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 8q13.1
Cellular Component:  cytoplasm; endoplasmic reticulum lumen; Golgi stack
Molecular Function:  thiol-dependent ubiquitin-specific protease activity
Biological Process:  mitotic cell cycle; protein K11-linked deubiquitination; protein K48-linked deubiquitination; protein ubiquitination
Reference #:  Q96JH7 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating protein VCIP135; DKFZp686G038; DUBA3; FLJ23132; FLJ60694; KIAA1850; valosin containing protein (p97)/p47 complex interacting protein 1; valosin containing protein interacting protein 1; valosin-containing protein (p97)/p47 complex-interacting protein p135; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; VCIP1; VCIP135; VCP/p47 complex-interacting 135-kDa protein; VCPIP1
Gene Symbols: VCPIP1
Molecular weight: 134,321 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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VCIP135

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene