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SIPA1
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression. Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Ras |
| Chromosomal Location of human Ortholog: 11q13.1 |
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Cellular Component:
cytoplasm; cytosol; Golgi apparatus; nucleus; perinuclear region of cytoplasm; plasma membrane; protein-containing complex
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Molecular Function:
GTPase activator activity; protein binding
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Biological Process:
activation of GTPase activity; adaptive immune response; cellular response to water deprivation; cytoskeleton organization; epithelial cell morphogenesis; establishment of epithelial cell polarity; intracellular signal transduction; negative regulation of cell adhesion; negative regulation of cell cycle; negative regulation of cell growth; regulation of small GTPase mediated signal transduction; signal transduction
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Reference #:
Q96FS4
(UniProtKB)
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Alt. Names/Synonyms: GTPase-activating protein Spa-1; MGC102688; MGC17037; p130 SPA-1; signal-induced proliferation-associated 1; signal-induced proliferation-associated gene 1; Signal-induced proliferation-associated protein 1; Sipa-1; SIPA1; SPA1
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Gene Symbols: SIPA1
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Molecular weight:
112,149 Da
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Basal Isoelectric point:
6.16
Predict pI for various phosphorylation states
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