SIPA1 GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression. Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component:  cytosol; membrane; nucleus; perinuclear region of cytoplasm; protein-containing complex; transport vesicle
Molecular Function:  GTPase activator activity; protein binding; protein C-terminus binding
Biological Process:  cellular response to water deprivation; cytoskeleton organization; intracellular signal transduction; negative regulation of cell adhesion; negative regulation of cell cycle; negative regulation of cell growth; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction
Reference #:  Q96FS4 (UniProtKB)
Alt. Names/Synonyms: GTPase-activating protein Spa-1; MGC102688; MGC17037; p130 SPA-1; signal-induced proliferation-associated 1; signal-induced proliferation-associated gene 1; Signal-induced proliferation-associated protein 1; Sipa-1; SIPA1; SPA1
Gene Symbols: SIPA1
Molecular weight: 112,149 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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