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SLCO4A1
Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate. Belongs to the organo anion transporter (TC 2.A.60) family. Ubiquitous, with the exception of spleen and leukocytes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of human Ortholog: 20q13.33 |
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Cellular Component:
plasma membrane
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Molecular Function:
organic anion transmembrane transporter activity; prostaglandin transmembrane transporter activity; protein binding; sodium-independent organic anion transmembrane transporter activity; thyroid hormone transmembrane transporter activity
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Biological Process:
monoatomic ion transport; prostaglandin transport; sodium-independent organic anion transport; thyroid hormone transport; transmembrane transport
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Reference #:
Q96BD0
(UniProtKB)
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Alt. Names/Synonyms: Colon organic anion transporter; OATP-E; OATP-RP1; OATP1; OATP4A1; OATPE; OATPRP1; Organic anion transporter polypeptide-related protein 1; organic anion transporting polypeptide E; Organic anion-transporting polypeptide E; POAT; SLC21A12; SLCO4A1; SO4A1; Sodium-independent organic anion transporter E; solute carrier family 21 (organic anion transporter), member 12; Solute carrier family 21 member 12; Solute carrier organic anion transporter family member 4A1; solute carrier organic anion transporter family, member 4A1
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Gene Symbols: SLCO4A1
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Molecular weight:
77,193 Da
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Basal Isoelectric point:
8.15
Predict pI for various phosphorylation states
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