|
islet-2
Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Note: This description may include information from UniProtKB.
|
| Protein type: DNA-binding |
| Chromosomal Location of Human Ortholog: 15q24.3 |
|
Cellular Component:
nucleus
|
|
Molecular Function:
DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; sequence-specific DNA binding
|
|
Biological Process:
negative regulation of neuron differentiation; neuron development; peripheral nervous system neuron development; regulation of transcription by RNA polymerase II; retinal ganglion cell axon guidance; spinal cord motor neuron cell fate specification; visceral motor neuron differentiation
|
|
Reference #:
Q96A47
(UniProtKB)
|
|
Alt. Names/Synonyms: FLJ10160; Insulin gene enhancer protein ISL-2; ISL LIM homeobox 2; ISL2; ISL2 transcription factor, LIM/homeodomain, (islet-2); Islet-2
|
|
Gene Symbols: ISL2
|
|
Molecular weight:
39,768 Da
|
|
Basal Isoelectric point:
8.64
Predict pI for various phosphorylation states
|
