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islet-2
Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of Human Ortholog: 15q24.3 |
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Cellular Component:
nucleus
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Molecular Function:
DNA binding; metal ion binding; sequence-specific DNA binding
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Biological Process:
negative regulation of neuron differentiation; neuron development; peripheral nervous system neuron development; regulation of transcription from RNA polymerase II promoter; retinal ganglion cell axon guidance; spinal cord motor neuron cell fate specification; visceral motor neuron differentiation
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Reference #:
Q96A47
(UniProtKB)
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Alt. Names/Synonyms: FLJ10160; Insulin gene enhancer protein ISL-2; ISL LIM homeobox 2; ISL2; ISL2 transcription factor, LIM/homeodomain, (islet-2); Islet-2
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Gene Symbols: ISL2
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Molecular weight:
39,768 Da
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Basal Isoelectric point:
8.64
Predict pI for various phosphorylation states
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