islet-2 Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 15q24.3
Cellular Component:  nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; sequence-specific DNA binding
Biological Process:  negative regulation of neuron differentiation; neuron development; peripheral nervous system neuron development; regulation of transcription by RNA polymerase II; retinal ganglion cell axon guidance; spinal cord motor neuron cell fate specification; visceral motor neuron differentiation
Reference #:  Q96A47 (UniProtKB)
Alt. Names/Synonyms: FLJ10160; Insulin gene enhancer protein ISL-2; ISL LIM homeobox 2; ISL2; ISL2 transcription factor, LIM/homeodomain, (islet-2); Islet-2
Gene Symbols: ISL2
Molecular weight: 39,768 Da
Basal Isoelectric point: 8.64  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene