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PHKB
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation. Belongs to the phosphorylase b kinase regulatory chain family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Protein kinase, regulatory subunit |
| Chromosomal Location of human Ortholog: 16q12.1 |
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Cellular Component:
cytosol; phosphorylase kinase complex; plasma membrane
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Molecular Function:
calmodulin binding; protein binding
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Biological Process:
generation of precursor metabolites and energy; glycogen metabolic process; protein phosphorylation
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Disease: Glycogen Storage Disease Ixb
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Reference #:
Q93100
(UniProtKB)
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Alt. Names/Synonyms: DKFZp781E15103; FLJ41698; KPBB; PHKB; Phosphorylase b kinase regulatory subunit beta; phosphorylase kinase beta-subunit; phosphorylase kinase regulatory subunit beta; Phosphorylase kinase subunit beta; phosphorylase kinase, beta
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Gene Symbols: PHKB
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Molecular weight:
124,884 Da
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Basal Isoelectric point:
6.5
Predict pI for various phosphorylation states
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