envoplakin Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. Belongs to the plakin or cytolinker family. Exclusively expressed in stratified squamous epithelia. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 17q25.1
Cellular Component:  cornified envelope; cytoplasm; cytosol; desmosome; intermediate filament; intermediate filament cytoskeleton; membrane
Molecular Function:  intermediate filament binding; structural molecule activity
Biological Process:  epidermis development; intermediate filament cytoskeleton organization; keratinization; keratinocyte differentiation; peptide cross-linking; wound healing
Reference #:  Q92817 (UniProtKB)
Alt. Names/Synonyms: 210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; Envoplakin; EVPK; EVPL; p210
Gene Symbols: EVPL
Molecular weight: 231,604 Da
Basal Isoelectric point: 6.56  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene