requiem Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells. Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF-kappa-B pathway. Belongs to the requiem/DPF family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component:  centrosome; cytosol; intracellular membrane-bounded organelle; nuclear chromatin; nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; H3K9me3 modified histone binding; lysine-acetylated histone binding; metal ion binding; protein binding; transcription corepressor activity
Biological Process:  apoptotic process; apoptotic signaling pathway; histone acetylation; negative regulation of myeloid progenitor cell differentiation; negative regulation of transcription by RNA polymerase II
Disease: Coffin-siris Syndrome 7
Reference #:  Q92785 (UniProtKB)
Alt. Names/Synonyms: Apoptosis response zinc finger protein; BAF45D; BRG1-associated factor 45D; D4, zinc and double PHD fingers family 2; DPF2; MGC10180; Protein requiem; REQ; REQU; requiem; requiem, apoptosis response zinc finger; ubi-d4; UBID4; Zinc finger protein ubi-d4
Gene Symbols: DPF2
Molecular weight: 44,155 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
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requiem

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene