RREB1 Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1. Belongs to the krueppel C2H2-type zinc-finger protein family. Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 6p24.3
Cellular Component:  cytoplasm; fibrillar center; nuclear body; nuclear speck; nucleus
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process:  multicellular organism development; negative regulation of transcription by RNA polymerase II; positive regulation of epithelial cell migration; positive regulation of lamellipodium morphogenesis; positive regulation of mammary gland epithelial cell proliferation; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of wound healing, spreading of epidermal cells; Ras protein signal transduction; regulation of transcription, DNA-templated; transcription by RNA polymerase II
Reference #:  Q92766 (UniProtKB)
Alt. Names/Synonyms: FINB; Finger protein in nuclear bodies; hindsight homolog; HNT; LZ321; Raf-responsive zinc finger protein LZ321; ras responsive element binding protein 1; Ras-responsive element-binding protein 1; RREB-1; RREB1; Zep-1; zinc finger motif enhancer binding protein 1; Zinc finger motif enhancer-binding protein 1; zinc finger motif-enhancer binding-protein 1
Gene Symbols: RREB1
Molecular weight: 181,420 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein