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AKAP1
Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. Isoform 1 is detected in thymus, prostate, testis, ovary, colon and small intestine (PubMed:8769136). Isoform 2 is highly expressed in testis and detected at much lower levels in kidney, pancreas, liver, lung and brain (PubMed:7499250). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Membrane protein, integral; Mitochondrial; RNA-binding |
| Chromosomal Location of Human Ortholog: 17q22 |
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Cellular Component:
cytosol; integral component of membrane; mitochondrial outer membrane; mitochondrion
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Molecular Function:
protein binding; protein kinase A regulatory subunit binding
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Biological Process:
blood coagulation; regulation of protein kinase A signaling
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Reference #:
Q92667
(UniProtKB)
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Alt. Names/Synonyms: A kinase (PRKA) anchor protein 1; A kinase anchor protein 1, mitochondrial; A-kinase anchor protein 1, mitochondrial; A-kinase anchor protein 149 kDa; A-kinase anchor protein, 149kD; A-kinase anchoring protein 1; AKAP; AKAP 149; AKAP1; AKAP121; AKAP149; AKAP84; D-AKAP-1; D-AKAP1; Dual specificity A-kinase-anchoring protein 1; dual-specificity A-kinase anchoring protein 1; MGC1807; PPP1R43; PRKA1; protein kinase A anchoring protein 1; Protein kinase A-anchoring protein 1; protein kinase A1; protein phosphatase 1, regulatory subunit 43; S-AKAP84; SAKAP84; Spermatid A-kinase anchor protein 84; TDRD17; testicular secretory protein Li 5; tudor domain containing 17
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Gene Symbols: AKAP1
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Molecular weight:
97,342 Da
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Basal Isoelectric point:
4.84
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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