MYO18A May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking. Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages. Strongly enhances natural killer cell cytotoxicity. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motor
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component:  actomyosin; cell surface; endoplasmic reticulum-Golgi intermediate compartment; Golgi membrane; myosin complex; trans-Golgi network
Molecular Function:  actin filament binding; ADP binding; ATP binding; DNA binding; protein binding
Biological Process:  actomyosin structure organization; asymmetric Golgi ribbon formation; cell migration; DNA metabolic process; Golgi organization; Golgi ribbon formation; Golgi vesicle budding; negative regulation of apoptotic process; positive regulation of opsonization; positive regulation of protein secretion; regulation of macrophage activation
Reference #:  Q92614 (UniProtKB)
Alt. Names/Synonyms: DKFZp686L0243; KIAA0216; MAJN; Molecule associated with JAK3 N-terminus; MY18A; MYO18A; myosin 18A; Myosin containing a PDZ domain; myosin containing PDZ domain; myosin XVIIIA; Myosin-XVIIIa; MYSPDZ; SP-A receptor subunit SP-R210 alphaS; SPR210; Unconventional myosin-XVIIIa
Gene Symbols: MYO18A
Molecular weight: 233,115 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene