THOC2 Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development. Belongs to the THOC2 family. Expressed in the hippocampus and the cerebral cortex. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Spliceosome
Chromosomal Location of human Ortholog: Xq25
Cellular Component:  nuclear speck; nucleoplasm; THO complex; THO complex part of transcription export complex; transcription export complex
Molecular Function:  protein binding
Biological Process:  generation of neurons; mRNA 3'-end processing; mRNA export from nucleus; neuron development; poly(A)+ mRNA export from nucleus; RNA export from nucleus; RNA splicing; viral mRNA export from host cell nucleus
Disease: Mental Retardation, X-linked 12
Reference #:  Q8NI27 (UniProtKB)
Alt. Names/Synonyms: CXorf3; dJ506G2.1; hTREX120; mental retardation, X-linked 12; mental retardation, X-linked 35; MRX12; MRX35; THO complex 2; THO complex subunit 2; Tho2; THOC2
Gene Symbols: THOC2
Molecular weight: 182,775 Da
Basal Isoelectric point: 8.67  Predict pI for various phosphorylation states
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THOC2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene