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STAG2
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Belongs to the SCC3 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: Xq25 |
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Cellular Component:
chromatin; chromosome; chromosome, centromeric region; cohesin complex; cytosol; fibrillar center; mitotic spindle pole; nuclear matrix; nucleolus; nucleoplasm; nucleus
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Molecular Function:
chromatin binding; protein binding
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Biological Process:
cell division; establishment of mitotic sister chromatid cohesion; meiotic cell cycle; mitotic spindle assembly; sister chromatid cohesion
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Disease: Holoprosencephaly 13, X-linked; Neurodevelopmental Disorder, X-linked, With Craniofacial Abnormalities
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Reference #:
Q8N3U4
(UniProtKB)
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Alt. Names/Synonyms: bA517O1.1; Cohesin subunit SA-2; DKFZp686P168; DKFZp781H1753; FLJ25871; HPE13; MKMS; NEDXCF; SA-2; SA2; SCC3 homolog 2; SCC3B; STAG2; Stromal antigen 2
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Gene Symbols: STAG2
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Molecular weight:
141,326 Da
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Basal Isoelectric point:
5.27
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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