FOG1 Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2. Belongs to the FOG (Friend of GATA) family. Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription regulation
Chromosomal Location of Human Ortholog: 16q24.2
Cellular Component:  nucleoplasm; transcription factor complex; transcriptional repressor complex
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; protein binding; RNA polymerase II activating transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II transcription factor binding; transcription factor binding
Biological Process:  atrial septum morphogenesis; atrioventricular valve morphogenesis; blood coagulation; cardiac muscle tissue morphogenesis; definitive erythrocyte differentiation; embryonic hemopoiesis; erythrocyte differentiation; granulocyte differentiation; megakaryocyte development; megakaryocyte differentiation; mitral valve formation; negative regulation of fat cell differentiation; negative regulation of interleukin-4 biosynthetic process; negative regulation of mast cell differentiation; negative regulation of protein binding; negative regulation of transcription by RNA polymerase II; outflow tract morphogenesis; platelet formation; positive regulation of interferon-gamma biosynthetic process; primitive erythrocyte differentiation; regulation of chemokine production; regulation of definitive erythrocyte differentiation; regulation of megakaryocyte differentiation; T-helper cell lineage commitment; transcriptional activation by promoter-enhancer looping; tricuspid valve formation; ventricular septum morphogenesis
Reference #:  Q8IX07 (UniProtKB)
Alt. Names/Synonyms: FOG; FOG-1; FOG1; Friend of GATA 1; Friend of GATA protein 1; friend of GATA-1; ZC2HC11A; ZFN89A; ZFPM1; Zinc finger protein 89A; Zinc finger protein multitype 1; Zinc finger protein ZFPM1; zinc finger protein, FOG family member 1; zinc finger protein, multitype 1; ZNF408; ZNF89A
Gene Symbols: ZFPM1
Molecular weight: 104,888 Da
Basal Isoelectric point: 8.14  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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