CDO1 Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. Belongs to the cysteine dioxygenase family. Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; EC; Other Amino Acids Metabolism - taurine and hypotaurine; Oxidoreductase
Chromosomal Location of Human Ortholog: 5q22.3
Cellular Component:  cytosol
Molecular Function:  cysteine dioxygenase activity; ferrous iron binding
Biological Process:  cysteine metabolic process; inflammatory response; L-cysteine catabolic process; lactation; oxidation-reduction process; response to amino acid; response to cAMP; response to ethanol; response to glucagon; response to glucocorticoid; sulfur amino acid biosynthetic process; taurine biosynthetic process
Reference #:  Q16878 (UniProtKB)
Alt. Names/Synonyms: CDO; CDO-I; CDO1; Cysteine dioxygenase type 1; Cysteine dioxygenase type I; cysteine dioxygenase, type I
Gene Symbols: CDO1
Molecular weight: 22,972 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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