SFRS7 Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. Belongs to the splicing factor SR family. Brain, liver, kidney and lung. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 2p22.1
Cellular Component:  cytoplasm; nucleoplasm
Molecular Function:  protein binding; protein domain specific binding; zinc ion binding
Biological Process:  cellular response to leukemia inhibitory factor; mRNA 3'-end processing; mRNA export from nucleus; mRNA processing; mRNA splicing, via spliceosome; negative regulation of mRNA splicing, via spliceosome; RNA export from nucleus; RNA splicing
Reference #:  Q16629 (UniProtKB)
Alt. Names/Synonyms: 9G8; AAG3; aging-associated protein 3; serine and arginine rich splicing factor 7; Serine/arginine-rich splicing factor 7; SFRS7; Splicing factor 9G8; Splicing factor, arginine/serine-rich 7; splicing factor, arginine/serine-rich 7, 35kDa; SR splicing factor 7; SRSF7
Gene Symbols: SRSF7
Molecular weight: 27,367 Da
Basal Isoelectric point: 11.83  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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