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SFRS7
Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. Belongs to the splicing factor SR family. Brain, liver, kidney and lung. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; RNA-binding; Spliceosome |
| Chromosomal Location of human Ortholog: 2p22.1 |
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Cellular Component:
cytoplasm; nuclear speck; nucleoplasm; nucleus
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Molecular Function:
mRNA binding; protein binding; protein domain specific binding; zinc ion binding
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Biological Process:
cellular response to leukemia inhibitory factor; mRNA processing; mRNA splicing, via spliceosome; mRNA transport; negative regulation of mRNA splicing, via spliceosome; RNA splicing
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Reference #:
Q16629
(UniProtKB)
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Alt. Names/Synonyms: 9G8; AAG3; aging-associated protein 3; serine and arginine rich splicing factor 7; Serine/arginine-rich splicing factor 7; SFRS7; Splicing factor 9G8; Splicing factor, arginine/serine-rich 7; splicing factor, arginine/serine-rich 7, 35kDa; SR splicing factor 7; SRSF7
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Gene Symbols: SRSF7
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Molecular weight:
27,367 Da
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Basal Isoelectric point:
11.83
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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