Zyxin Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression. Belongs to the zyxin/ajuba family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 7q34
Cellular Component:  cell-cell adherens junction; cytosol; focal adhesion; nucleus; phagocytic vesicle; stress fiber
Molecular Function:  metal ion binding; protein binding
Biological Process:  cell-cell signaling; cell-matrix adhesion; cellular response to interferon-gamma; integrin-mediated signaling pathway; regulation of inflammatory response; stress fiber assembly; transforming growth factor beta receptor signaling pathway; viral process
Reference #:  Q15942 (UniProtKB)
Alt. Names/Synonyms: ESP-2; HED-2; ZYX; Zyxin; Zyxin-2
Gene Symbols: ZYX
Molecular weight: 61,277 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein