EZH2 Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily. Expressed in many tissues. Overexpressed in numerous tumor types including carcinomas of the breast, colon, larynx, lymphoma and testis. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Methyltransferase; Methyltransferase, protein lysine
Chromosomal Location of Human Ortholog: 7q36.1
Cellular Component:  chromosome, telomeric region; cytoplasm; ESC/E(Z) complex; nuclear chromatin; nucleoplasm; nucleus; pronucleus
Molecular Function:  chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; histone methyltransferase activity; histone methyltransferase activity (H3-K27 specific); histone-lysine N-methyltransferase activity; primary miRNA binding; promoter-specific chromatin binding; protein binding; protein-lysine N-methyltransferase activity; ribonucleoprotein complex binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription corepressor activity
Biological Process:  cardiac muscle hypertrophy in response to stress; cellular response to hydrogen peroxide; cellular response to trichostatin A; cerebellar cortex development; chromatin organization; chromatin silencing at telomere; DNA methylation; G1 to G0 transition; hepatocyte homeostasis; hippocampus development; histone H3-K27 methylation; histone H3-K27 trimethylation; histone methylation; liver regeneration; negative regulation of DNA-binding transcription factor activity; negative regulation of epidermal cell differentiation; negative regulation of G0 to G1 transition; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression, epigenetic; negative regulation of retinoic acid receptor signaling pathway; negative regulation of striated muscle cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription elongation from RNA polymerase II promoter; negative regulation of transcription, DNA-templated; positive regulation of cell cycle G1/S phase transition; positive regulation of cell proliferation; positive regulation of dendrite development; positive regulation of epithelial to mesenchymal transition; positive regulation of GTPase activity; positive regulation of MAP kinase activity; positive regulation of protein serine/threonine kinase activity; protein localization to chromatin; regulation of circadian rhythm; regulation of gliogenesis; regulation of transcription, DNA-templated; response to estradiol; response to tetrachloromethane; rhythmic process; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
Disease: Weaver Syndrome
Reference #:  Q15910 (UniProtKB)
Alt. Names/Synonyms: enhancer of zeste 2; Enhancer of zeste homolog 2; enhancer of zeste homolog 2 (Drosophila); ENX-1; ENX1; EZH1; EZH2; Histone-lysine N-methyltransferase EZH2; KMT6; KMT6A; Lysine N-methyltransferase 6; MGC9169
Gene Symbols: EZH2
Molecular weight: 85,363 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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