TRIP8 Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes. Belongs to the JHDM2 histone demethylase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 10q21.3
Cellular Component:  chromatin; intracellular; nucleoplasm; nucleus
Molecular Function:  chromatin DNA binding; dioxygenase activity; histone demethylase activity (H3-K9 specific); metal ion binding; protein binding; thyroid hormone receptor binding
Biological Process:  blood coagulation; histone H3-K9 demethylation; regulation of transcription, DNA-templated; transcription, DNA-dependent
Reference #:  Q15652 (UniProtKB)
Alt. Names/Synonyms: DKFZp761F0118; FLJ14374; JHD2C; JHDM2C; JMJD1C; jumonji domain containing 1C; Jumonji domain-containing protein 1C; KIAA1380; Probable JmjC domain-containing histone demethylation protein 2C; RP11-10C13.2; thyroid hormone receptor interactor 8; thyroid receptor interacting protein 8; Thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8; TRIP8
Gene Symbols: JMJD1C
Molecular weight: 284,525 Da
Basal Isoelectric point: 7.95  Predict pI for various phosphorylation states
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TRIP8

Protein Structure Not Found.


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