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TRIP8
Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes. Belongs to the JHDM2 histone demethylase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 10q21.3 |
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Cellular Component:
chromatin; histone deacetylase complex; nucleoplasm
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Molecular Function:
chromatin DNA binding; dioxygenase activity; histone H3K9 demethylase activity; metal ion binding; nuclear thyroid hormone receptor binding; protein binding; transcription coregulator activity
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Biological Process:
blood coagulation; chromatin remodeling; DNA-templated transcription; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II
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Reference #:
Q15652
(UniProtKB)
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Alt. Names/Synonyms: DKFZp761F0118; FLJ14374; JHD2C; JHDM2C; JMJD1C; jumonji domain containing 1C; Jumonji domain-containing protein 1C; KDM3C; KIAA1380; Probable JmjC domain-containing histone demethylation protein 2C; RP11-10C13.2; thyroid hormone receptor interactor 8; thyroid receptor interacting protein 8; Thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8; TRIP8
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Gene Symbols: JMJD1C
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Molecular weight:
284,525 Da
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Basal Isoelectric point:
7.95
Predict pI for various phosphorylation states
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