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EEF2K
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. Belongs to the protein kinase superfamily. Alpha-type protein kinase family. Note: This description may include information from UniProtKB.
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| Protein type: ATYPICAL group; Alpha family; EC 2.7.11.20; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation; eEF2K subfamily |
| Chromosomal Location of human Ortholog: 16p12.2 |
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Cellular Component:
cytoplasm; cytosol; dendritic spine; glutamatergic synapse; postsynaptic density
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Molecular Function:
ATP binding; calcium ion binding; calmodulin binding; elongation factor-2 kinase activity; protein kinase activity; translation factor activity, RNA binding
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Biological Process:
cellular response to anoxia; cellular response to brain-derived neurotrophic factor stimulus; cellular response to calcium ion; cellular response to cAMP; cellular response to insulin stimulus; myosin II filament disassembly; negative regulation of apoptotic process; positive regulation of dendritic spine morphogenesis; positive regulation of endocytosis; positive regulation of synapse assembly; protein autophosphorylation; regulation of protein autophosphorylation; regulation of translation at postsynapse; response to ischemia; response to prolactin; translational elongation
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Reference #:
O00418
(UniProtKB)
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Alt. Names/Synonyms: alternative protein EEF2K; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase; calmodulin-dependent protein kinase III; CaMKIII; eEF-2 kinase; eEF-2K; EEF2K; EF2K; elongation factor 2 kinase; elongation factor-2 kinase; eukaroytic elongation factor 2 kinase; Eukaryotic elongation factor 2 kinase; eukaryotic elongation factor-2 kinase; HSU93850; MGC45041
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Gene Symbols: EEF2K
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Molecular weight:
82,144 Da
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Basal Isoelectric point:
5.16
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Growth And Differentiation Control by MAPKs
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Regulation of P38 MAPKs
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Translational Control
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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