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NHERF-2
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 16p13.3 |
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Cellular Component:
apical plasma membrane; endomembrane system; nucleus; plasma membrane
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Molecular Function:
beta-catenin binding; phosphatase binding; protein binding; protein C-terminus binding; signaling receptor binding
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Biological Process:
protein-containing complex assembly
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Reference #:
Q15599
(UniProtKB)
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Alt. Names/Synonyms: E3KARP; MGC104639; Na(+)/H(+) exchange regulatory cofactor NHE-RF2; NHE3 kinase A regulatory protein E3KARP; NHE3 regulatory factor 2; NHE3RF2; NHERF-2; NHERF2; NHRF2; OCTS2; SIP-1; SIP1; SLC9A3 regulator 2; SLC9A3R2; Sodium-hydrogen exchanger regulatory factor 2; sodium/hydrogen exchanger 3 kinase A regulatory protein; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; Solute carrier family 9 isoform A3 regulatory factor 2; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2; SRY-interacting protein 1; TKA-1; Tyrosine kinase activator protein 1
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Gene Symbols: SLC9A3R2
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Molecular weight:
37,414 Da
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Basal Isoelectric point:
7.8
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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